منابع مشابه
Alpha-Lipoic Acid
OBJECTIVE: To evaluate the efficacy and safety of oral treatment with the antioxidant alpha-lipoic acid (ALA) in NIDDM patients with cardiac autonomic neuropathy (CAN), assessed by heart rate variability (HRV). RESEARCH DESIGN AND METHODS: In a randomized, double-blind placebo-controlled multicenter trial (Deutsche Kardiale Autonome Neuropathie [DEKAN] Study), NIDDM patients with reduced HRV we...
متن کاملAlpha Lipoic Acid
Alpha lipoic acid, or just lipoic acid (LA), is a unique and potent antioxidant. It can deliver antioxidant activity in both fatand water-soluble mediums, and it is capable of having an antioxidant effect in both its oxidized (LA) and reduced (DHLA [dihydrolipoic acid]) forms (Goraca et al., 2011). This effectively allows LA to deliver its antioxidant effect to any cell or tissue type, as well ...
متن کاملAlpha-lipoic Acid Monograph
Introduction Alpha-lipoic acid (ALA – also known as thioctic acid) was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs cycle. In the 1980s, the scientific community realized alpha-lipoic acid is a powerful antioxidant. Several qualities distinguish alpha-lipoic acid from other antioxidants: ALA can be synthesized by animals and humans;1 it neu...
متن کاملDiabetes and Alpha Lipoic Acid
Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease. This has prompted several investigations into the use of antioxidants as a complementary therapeutic approach. Alpha lipoic acid, a naturally occurring dithiol compound which plays an essential role in mitochondrial bioenergetic rea...
متن کاملAlpha-lipoic acid supplementation and diabetes
Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease. Alpha-lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes...
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ژورنال
عنوان ژورنال: Neurologie pro praxi
سال: 2020
ISSN: 1213-1814,1803-5280
DOI: 10.36290/neu.2020.026